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Several factorsin addition to GSHhave been implicated in the cellular protection against oxidative stress, most of them being under the control of the master regulator NRF2 46
The first-in-human Phase I clinical trial of JPH203 in patients with advanced solid tumors demonstrated improved therapeutic effects, particularly in two patients with CRC treated daily with intravenous JPH203 [73]
62 LiuD.HuangC.GuoJ.ZhangP.ChenT.WangZ.et al (2019)
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