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424 Moreover, the two components of the G3P shuttle (including GPD1 in the cytoplasm and GPD2 in the mitochondria) are up-regulated in mRNA and protein levels in diabetic islets, thus ensuring the transfer of electrons from NADH produced in glycolysis to mitochondria

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Furthermore, mangiferin prevents neuronal death by preserving neuronal ATP levels, suppressing cytochrome c release, and inhibiting caspase activation (Walia et al., 2021)