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Its triple GIP/GLP-1/glucagon agonist mechanism produced the most striking weight-loss numbers ever reported in a Phase 2 trial of an injectable peptide, and its broad TRIUMPH Phase 3 program is poised to expand understanding of how triple receptor modulation affects obesity, diabetes, liver disease, cardiovascular risk, sleep apnea, and musculoskeletal health

GSEA analysis indicated that fatty acid metabolism was significantly upregulated in the CKO group compared to that in the Gly group (Fig

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1 Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University of Jerusalem, Jerusalem, 2 Obesity and Metabolism Laboratory, The Institute for Drug Research, School of Pharmacy, Faculty of M, Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem, 3 Hadassah Medical Center, Department of Endocrinology, Hebrew University of Jerusalem, Jerusalem, Israel