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++ Step 5(ii): Weight the risk-adjusted county-level FFS expenditures determined in Step 5(i) according to the ACO's proportion of assigned beneficiaries in the county, determined in accordance with 425.601(d)(1), 425.603(f)(1), or 425.654(b)(1), as applicable, for each of the populations of beneficiaries by Medicare enrollment type

It aims to determine if those who receive escalating doses of semaglutide over two months will drink and smoke less than participants who receive a placebo injection

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Moreover, CS-induced COPD disrupted gut microbiota, reducing Akkermansia and Escherichia-Shigella , and activated the STAT3/NCOA4 pathway, promoting oxidative stress, inflammation, and ferritinophagy