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In addition to IL-4, several other cytokines, including TNF-, IL-1, IL-6, and IL-8, contribute to CD (163)

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Discovery of LHRH antagonists resulted in therapeutic improvement over agonists as they cause an immediate and dose-related inhibition of LH and FSH by competitive blockade of the LHRH receptors

doi: 10.3389/fphar.2026.1796921 Received 28 January 2026 Revised 23 April 2026 Accepted 27 April 2026 Published 14 May 2026 Volume 17 - 2026 Edited by Arindam Kuila, Banasthali University, India Reviewed by Haiyun Xu, Wenzhou Medical University, China Lei Li, Second Military Medical University, China Updates Copyright 2026 Gao, Luo, Chen, Mi, He, Shang, Sui and Zheng