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Our internal circadian clock regulates rhythms of wakefulness and sleep, as well as cardiovascular, digestive, metabolic, and immune functions, and coordinates them with environmental cues such as cycles of light and darkness

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Both diarrhea (33.3% at 12 mg) and constipation (16.7% at 12 mg) were reported in Phase 2, and both can produce lower abdominal cramping through different mechanisms researchers sometimes describe this presentation as retatrutide gas pain or trapped-gas-style pressure rather than classic stomach cramps

Common Gastrointestinal Side Effects and Management Strategies The majority of patients encounter their most significant digestive adjustments within the First 48 Hours following their weekly dose