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For example, activation of transient receptor potential ankyrin 1 (TRPA1) induces Ca influx, promoting calmodulin-dependent protein kinase II (CaMKII) phosphorylation, and Nrf2 nuclear translocation, which upregulates GPX4 to inhibit ferroptosis in high-glucose-exposed endothelial cells, thereby improving cell migration, proliferation, and tube formation to enhance diabetic wound healing [87]

Treatment with FOXO4-DRI reduces hydroxyproline content in lung tissue, a direct measure of collagen deposition, and improves lung histology assessed by hematoxylin-eosin and Masson trichrome staining

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Follow-up bloodwork should occur at 8 to 12 weeks after starting therapy, then quarterly during ongoing use