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FIGURE 15-3: Role of the pentose phosphate pathway in the glutathione peroxidase reaction of erythrocytes

Regionally, North America and Europe lead in consumption, accounting for over 60% of the global market

SURPASS-4, a multicenter open-label RCT comparing treatment with tirzepatide and insulin glargine in T2D patients at increased CV risk for a median of 85 weeks, was the only study in the SURPASS program to include the change from baseline in eGFR and UACR and occurrence of eGFR decline of at least 40%, renal death, progression to end-stage kidney disease or new-onset MA among the prespecified analyses [48]

The patients were administered a highly bioavailable form of luteolin (co-ultramicronized with PEA) for 90 days