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It is often associated with pregnancy or hormonal medications

In vitro barrier models using Caco-2 cells (gut epithelium) or brain endothelial cells could be employed to test the hypothesis that microbiota metabolites, such as butyrateeither administered directly or derived from patient-derived fecal microbiota culturescan strengthen epithelial and endothelial barrier function and reduce oxidative stress [40]

Chronic ethanol consumption results in atypical liver injury in copper/zinc superoxide dismutase deficient mice