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Upon apoptosis, activation of Bax (and Bak) is initiated by interaction with BH3-only activators that trigger Bax (and Bak) conformational changes, promoting an extended membrane-inserted structure

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To explore the functional relevance of these DEGs, gene ontology (GO) enrichment analysis was conducted, revealing that the altered genes were primarily involved in immune response regulation, cytokine production, oxidative stress response, and mitochondrial functions