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All drugs of abuse, from nicotine to heroin, cause a particularly powerful surge of dopamine The likelihood that the use of a drug or participation in a rewarding activity will lead to addiction is directly linked to the speed with which it promotes dopamine release, the intensity of that release, and the reliability of that release. How Addiction Hijacks the Brain, Harvard Mental Health Letter Addiction occurs when your brain develops a tolerance to the dopamine being released and you continue to use the drug in order to recapture that initial good feeling