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Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine Noxidegenerating pathway, modulates platelet responsiveness and thrombosis risk

Current clinical guidance recommends: Discontinuing Wegovy at least 2 months before attempting conception to allow full clearance Continuing reliable contraception until actively trying to conceive, given that weight loss may restore ovulation unexpectedly Stopping the medication immediately and consulting a provider upon confirmed pregnancy For women with PCOS planning pregnancy, coordinating a transition plan with both gynecology and endocrinology before stopping Wegovy Wegovy and breastfeeding No human safety data exists for semaglutide use during breastfeeding

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