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Low efficacy, weight gain, and hypoglycemia are the main pitfalls of previous treatments for T2DM

127 It is also observed that suppressing the expression of PKM2 (Pyruvate Kinase M2) deactivates the AKT and/or mTOR signalling pathway, thereby decreasing the SREBP-1c expression which inhibits the generation of fatty acid by inhibiting the FASN gene transcription, resulting in the inhibited tumor cell growth

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