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However, in keeping with our data on receptor pharmacology, increasing the dose to 30 nmol kg 1 , tenfold higher than maximal doses from our studies, shows that tirzepatide does have insulinotropic activity in Glp1r -/- mice or in the presence of a GLP-1R antagonist 5 , demonstrating that tirzepatide can engage the GIPR in mouse beta cells at sufficiently high concentrations

[Research Methodology] The study area of this paper covers highly developed coastal areas in Busan, South Korea

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[DOI] [PubMed] [Google Scholar] 73.Green C.J., Henriksen T.I., Pedersen B.K., Solomon T.P.J