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SUMO2 and SUMO3 interacted and modified several AR-associated coregulators (p300, SRC2, BAF proteins) and pioneering factors (FOXA1, HOXB13) associated with ARE-bound AR, demonstrating that SUMOylation amplified interactions with its transcriptional complex

Oxidative stress and mitochondrial dysfunction Mitochondria are not only the primary site of ROS production but also major targets of oxidative stress

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