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When examining a composite cardio outcomes endpoint (death from CV disease, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina), the ELIXA trial suggested that GLP-1s did not increase cardiovascular event risk (hazard ratio of 1.02)

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Therefore, GLP-1RAs have emerged as one of the recommended pharmacological interventions for type 2 diabetes mellitus, especially for patients with cardiovascular risk factors and coexisting comorbidities (e.g., chronic kidney disease) [5]

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