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While its hard to generalize about effects, Piomelli notes that for a person in their 20s to 40s, weighing anywhere from 50-80kg (110-175lbs), 10-20mg of THC per serving would be enough to produce a noticeable buzz definitely enough to cause a full-blown high for someone who isnt a regular user. I always say: know before you go, says Harvard neuroscientist Staci Gruber, who directs the longest-running study of medical cannabis use in the United States