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Why L-Citrulline Supplementation Outperforms L-Arginine Despite L-arginine's direct role in NO production, L-citrulline offers several advantages as a supplement: Superior Bioavailability - Oral L-arginine undergoes extensive breakdown in the intestines and liver, with approximately 40% degraded during first-pass metabolism

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However, the FDA previously announced in February 2025 that the supply issues related to Ozempic and its weight loss counterpart, Wegovy, have been resolved, effectively decreasing the need for compounded alternatives

Most users tolerate this range without gastrointestinal upset, though doses above 5 grams may cause loose stools