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The small intestine has natural defenses against bacterial colonization, including gut motility, stomach acid, and immune surveillance

For example, the Lactobacillus rhamnosus GG strain may modulate intestinal immune cells to reduce the release of inflammatory cytokines ( 4.3 The role of B vitamins and vitamin D In children with ASD, abnormalities in methylation metabolism have been widely documented, including a decreased S-adenosylmethionine to S-adenosylhomocysteine (SAM/SAH) ratio and elevated homocysteine levels ( 4.4 Trace elements and nutritional supplementation Children with ASD commonly exhibit elevated oxidative stress, characterized by a reduced glutathione-to-oxidized glutathione (GSH/GSSG) ratio and increased levels of malondialdehyde (MDA), a marker of lipid peroxidation ( 4.5 The ketogenic diet Mechanistically, the ketogenic diet (KD) works by restricting carbohydrate intake, thereby prompting the body to produce ketone bodies as an alternative energy source

Additionally, MAOB KO (129/SvImJ strain) 35 and WT littermates, both male and female, on a C57BL/6 J background and aged 8 to 10 weeks, were used for the MAOB-OE model

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