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Histology results Before the initiation of therapy, at 10 min after injury induction, a large hemorrhagic zone was present over the lateral and posterior white columns in all of the rats, but there were no changes in the gray matter

However, considering its important effects on innate immunity, long-term inhibition of the inflammasome comes with a risk of infection [10], which limits the clinical application of NLRP3 inflammasome inhibitors