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The Blunted Serotonergic Response Problem A subtler risk than frank serotonin syndrome is that the disrupted SERT binding and 5-HT1A receptor changes seen in isotretinoin users may cause 5-HTP's effect to become unpredictable

Of note, a study using labelled pyridoxine in pregnant and non-pregnant control rats did not find significant differences in the intestinal absorption of radioisotope between the two groups (Reference Wang and Trumbo39)

According to the National Institutes of Health, retinoic acid can support overall skin health and lessen the roughness of facial skin, reduce hyperpigmentation, and decrease the number and severity of fine facial wrinkles caused by photo-aging. It can also reduce inflammation and acne scarring