semaglutide weight loss brain cells Brainstem Neurons Hold Key to Semaglutide's Effects What Is GLP-1 and Why

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The benefits in ASCVD risk reduction with GLP-1RA are evidenced by 14% risk reduction in cardiovascular mortality with an NNTB of 207 to prevent one event, 13% MACE reduction with an NNT of 67 to prevent one event and 12% risk reduction in stroke with an NNT of 335 to prevent one event, along with their favourable safety profile of 6% increased overall adverse events

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Moreover, GLP-1RAs suppress neuroinflammation in preclinical studies [101, 146], and exenatide, given either twice daily or once weekly, improved disease activity scores in people with Parkinsons disease [169, 170]