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Similarly, pH-sensitive optical probes have been used to map extracellular acidification associated with increased glycolytic flux and poor vascular perfusion (185, 186)

[10] Additive depressant effects occur with other class I antiarrhythmics, phenytoin, and volatile anesthetics, while epinephrine-containing local formulations may potentiate vasoconstriction and delay systemic absorption-beneficial for prolonging local anesthesia but hazardous if inadvertent intravascular injection occurs