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Additionally, four genes, plus one continuous gene deletion, are associated with peripheral neuropathy, a mechanism of potential importance to CVS (4, 6), and thus also were also elevated to Possibly related status (Table 5, genes in yellow font)

Many patients find that combining healthy lifestyle changes with GLP-1 therapy delivers superior results compared to berberine alone

Alternative evidence-based interventions, including structured lifestyle programmes, psychological support, other pharmacological options, and bariatric surgery (for those meeting criteria), may be more readily accessible and should be considered as part of an individualised treatment plan

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