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The compound has been characterized in rat and mouse cognitive-research models principally scopolamine-induced cognitive impairment, aged-rat cognitive decline, and the APP/PS1 transgenic Alzheimers disease model with reported effects on hippocampal synaptogenesis, dendritic spine density, and Morris water maze performance

As a second approach to test for hyperoxidation, we used an SDSPAGEbased redox shift assay to monitor the redox state of the single cysteine in mature endogenous Prx1, i.e., the peroxidatic cysteine C91 (Fig 4F)

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All the murine models were then presented with a fibrin sealing agent, where some murine models were also presented with thymosin beta 4 (TB-500)