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Metabolomic analyses of reactive astrocytes in mouse models have revealed that late-stage AD is associated with synaptic dysfunction and neurotransmitter imbalances, primarily due to impaired glutamine synthesis 71

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Disappointingly, similar studies performed in patients with PD have drawn inconsistent conclusions in which results from a small RCT did not show any significant improvement in the tamoxifen group compared with the placebo group (Teloken et al., 1999)