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A systematic review published in Current Treatment Options in Psychiatry analyzed 81 human and animal studies and concluded that GLP-1 receptor agonists showed potential benefits for depressive symptoms, anxiety, cognitive function, binge eating, and alcohol or substance use disorders (3 Trusted Source The Impact of GLP-1 Receptor Agonists (GLP-1 RAs) on Mental Health: A Systematic Review Go to source)

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Full tolerancewhere nausea becomes rare or minimaltypically develops within 4 to 8 weeks of regular semaglutide therapy