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Inhibition of de novo lipogenesis also blocks glycolysis and induces FAO, demonstrating that de novo lipogenesis is required for fibroblast activation (220)

27 Importantly, meta-analyses suggest that patients with lean MASLD may have a higher all-cause mortality rate than those with nonlean MASLD (hazard ratio 1.61, 95% confidence interval 1.371.89), independent of traditional risk factors

Bars represent the average plaque number of n = 2 cell layer infections shown as individual dots and normalised to buffer control in at least two different Nb concentrations