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In a pivotal study published in the Journal of Orthopedic Research, researchers created 0.8 cm segmental bone defects in rabbit radius bones and compared healing across treatment groups

Early pregnancy monitoring Since HCG levels are expected to rise during early pregnancy, if there are any concerns about the development of the pregnancy, especially when there was a history of miscarriage or symptoms such as bleeding or abdominal pain, a series of HCG level tests will be done a few days to monitor the rate of the increase

Cell 124 , 407421 (2006)

Furthermore, mutations in the juxtamembrane domain led to tumorigenesis in an in vitro trial (Graveel et al., 2013)