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Eye cream study (41 women, 12 weeks): GHK-Cu eye cream outperformed both placebo and vitamin K cream for reducing wrinkles and increasing skin density around the eyes (PMID 26236730)

Timing is clinically important: GH is predominantly secreted during slow-wave sleep, and dosing 30 to 60 minutes before sleep allows Ipamorelin to work in synchrony with the natural nocturnal GH secretion cycle

In addition, we have also found an improvement in the freshness, quality and uniformity of the treated skin (Figures 1-8)

In U87 and T98G cells treated with metformin and simvastatin, there was a significant downregulation in the expression of the mature form of SREBP2, MBTPS1, and SCAP