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while A treatment was shown to increase Rac1 activity, the expression of constitutively active Rac1 was able to increase the production of A via increasing gamma-secretase-mediated cleavage of amyloid precursor protein (APP) (Wang et al., 2009)

[DOI] [PMC free article] [PubMed] [Google Scholar] [106].Potts JE, Gray LJ, Brady EM, Khunti K, Davies MJ, Bodicoat DH

Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis

In a Phase 1 randomized, double-blind clinical study targeting obese participants (NCT04478708), AMG133 demonstrated acceptable safety, tolerability, and significant dose-dependent weight loss