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doi: 10.1300/J092v11n01_02 37 HewlettSKirwanJBodeCCrampFCarmonaLDuresEet al

The mechanism work on this is active: GLP-1R is expressed in cardiovascular tissue, and receptor activation there appears to modulate inflammation, endothelial function, and possibly plaque biology through pathways that are not obviously downstream of insulin or appetite regulation

154 KorotkovaT

122 Notably, the beneficial effects of liraglutide on tau phosphorylation were not replicated by insulin therapy, suggesting that GLP-1RAs confer neuroprotection via mechanisms distinct from insulin signaling pathways