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Gaseous components include nitrogen (N2) oxygen (O2) carbon dioxide (CO2) carbon monoxide (CO) acetaldehyde methane hydrogen cyanide (HCN) ammonia many others Particulate components include carboxylic acids phenols water nicotine paraffin waxes many others Note that certain chemicals are not limited to only one particular phase (gas or particulate)

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Therefore it seems that nicotine harms should not be exaggerated when legitimate concerns are framed, for example with concerns raised by animal studies but scant human evidence that it causes permanent brain damage when decoupled from all the other toxins in inhaled smoke or that nicotine itself either causes or strongly promotes cancer