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GH-IGF Signaling: Convergence With Gonadotropin Signaling While male and female reproductive systems are clearly different, the response to gonadotropins including cell proliferation and sex steroid synthesis/release is largely biochemically similar (Figure 2)

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Inflammation increases the bioactive molecules in the tumor microenvironment, such as cytokines, chemokines, growth factors, and matrix-modifying enzymes (e.g., MMPs), which in turn raises the risk of cancer development [80]

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