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The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions:explanation and elaboration

During the stress phase, myocardial blood flow is increased using: Exercise stress, like testing on a treadmill or bike, while keeping an eye on the patients heart rate with an EKG Pharmacologic stress, employing agents such as Lexiscan (regadenoson) or adenosine At the height of stress, a radiotracer like technetium-99m sestamibi or tetrofosmin is injected

Any elderly patient experiencing new or worsening neurological symptoms despite B12 treatment should be referred back to their GP for reassessment, as alternative diagnoses must be considered

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