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The third embodiment of the present invention provides a process for the preparation of H-Glu(OtBu)-Gly-Thr(tBu)-Phe-Thr(tBu)-Ser(tBu)-Asp(OtBu)-Val-Ser(tBu)-Ser(tBu)- Tyr(tBu)-Leu-Glu(OtBu)-Gly-Gln(Trt)-Ala-Ala-Lys(Boc)-Glu(OtBu)-Phe-Ile-Ala-Trp(Boc)- Leu-Val-Arg(Pbf)-Gly-Arg(Pbf)-Gly-Resin, comprising

Patients should never adjust their prescribed dose without consulting their healthcare provider, as semaglutide requires gradual dose escalation to minimize gastrointestinal adverse effects

Eat smaller, balanced meals to reduce nausea and digestive discomfort

The Food and Drug Administration (FDA) reports that 5% of semaglutide users suffer from constipation