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Other studies have shown issues with the ability of the enzyme dopamine beta hydroxylase which catalyzes dopamine into norepinephrine and the norepinephrine transporter enzyme which is involved in the reuptake of norepinphrine into the synaptic terminals (13, 14)

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Key factors hindering the healing of diabetic wounds include persistent high level of reactive oxygen species (ROS), excessive inflammatory cells and cytokines in the wound microenvironment, insufficient new blood vessel formation, and weakened cell proliferation 21,22

Most pharmaceutical companies stack the deck by requiring lifestyle interventions that independently produce results