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The thionin II activity remained at elevated temperature (100C, 15 min) but lost its antifungal property in the presence of cations such as Na + , K + , Ca 2+ , and Mg 2+ (Schmidt et al., 2019)

By activating autophagy, Astragaloside IV prevents activation and assembly of NLRP3 inflammasome and reduces the release of pro-inflammatory cytokines in the liver and kidneys injured by CP (Qu et al., 2019)

10.1080/03639045.2020.1730396 70 NabiB.RehmanS.KhanS.BabootaS.AliJ

Emerging paradigms: novel mechanisms and druggable targets Beyond these established pathways, recent discoveries have unveiled novel mechanistic layers and therapeutic targets, expanding the intervention landscape for mitochondrial optic neuropathies