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Introduction and Overview 1

Metabolic tracer studies in humans demonstrate that adipose tissue derived FAs account for the majority of hepatic TAGs in FLD patients, suggesting that dysregulation of adipocyte lipolysis is a major mechanism of diet-induced FLD (203) (Figure 5)

The study identified 5-Amino-1MQ from a series of 1-methylquinolinium analogues through PAMPA and Caco-2 permeability screening and confirmed its high selectivity for NNMT over related SAM-dependent methyltransferases

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