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Here is a simplified version of the titration approach used in the landmark Phase 2 obesity trial published in the New England Journal of Medicine

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Los mecanismos mediante los cuales la L-Carnitina influye en PGC-1 no estn completamente elucidados pero pueden involucrar la modulacin del estado energtico celular reflejado en la relacin AMP/ATP y la activacin de AMPK, una protena quinasa sensora de energa que fosforila y activa PGC-1