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It is used under medical supervision when a patients natural GH levels are abnormally low

Though it has similar effects, IGF-1 LR3 does not adhere to IGF binding proteins as strongly as IGF-1

Substances frequently used as supplements to AAS include alcohol, amphetamine, caffeine, cannabinoids, clenbuterol, cocaine, codeine, creatine, ephedrine, erythropoietin, gamma hydroxybutyrate, GH, heroin, human chorionic gonadotropin, insulin, IGF-I, tamoxifen, tobacco, and many others (Ip et al., 2012, Sagoe, McVeigh, Bjornebekk et al., 2015, Borjesson, Garevik, Dahl et al., 2016)

That makes native IGF-I awkward as an experimental tool, because in any system containing serum or secreted IGFBPs the concentration a researcher adds is not the concentration the receptor sees