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Previous studies have shown that under cholesterol depletion, NPC1L1 translocates from the endocytic recycling compartment (ERC) to the plasma membrane, while cholesterol binding triggers its clathrin and adaptor protein 2-dependent endocytosis to the ERC [42, 43]

Figure 4C)

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From Pubchem IUPAC Name: (4S)-4-[[(2S)-2-aminopropanoyl] amino]-5-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl] amino]-5-oxopentanoic acid Synonyms: Epithalone, alanyl-glutamyl-aspartyl-glycine, epitalon, epithalon Molecular Formula: C14H22N4O9 Molecular Weight: 390.35 g/mol Sequence: Ala-Glu-Asp-Gly CAS number: 307297-39-8 PubChem CID: 219042 Epithalon was initially researched and developed in Russia by Dr