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Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart

Among adults over 18, 43% were overweight and 16% were considered obese

These results indicate that AMPK pathway is involved in the regulation of metformin on GLP-1R level and PKA phosphorylation in PA-treated HUVECs

GLP-1 receptor agonists, including tirzepatide, are thought to exert neuroprotective effects through the modulation of neuroinflammation, the hypothalamic-pituitary-adrenal (HPA) axis, and neurotransmitter pathways, which play key roles in mood regulation and stress response ( The study has several strengths, including the use of a large, real-world database from the TriNetX network, which enhances the generalizability of our findings