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MOTS-c activates AMPK pathways that improve GLUT4 glucose transport, restoring cellular glucose uptake without the GI side effects of metformin.5 For adults managing prediabetes or metabolic syndrome, this is clinically significant

This is the first new medication approved since 2014 as an addition to diet and physical activity indicated for adults with obesity (initial BMI 30 kg/m2) or overweight (initial BMI 27 kg/m2) with at least one weight-related medical condition

The absorbance was measured at 570 nm using a microplate reader (Model 680, Bio-Rad)

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