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Despite their growing use, the optimal perioperative management of patients receiving these agents remains uncertain

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Side-by-Side Comparison Why Researchers Combine CJC-1295 + Ipamorelin The pituitary has two distinct pathways for growth hormone release: GHRH pathway the on signal (CJC-1295 activates this) Ghrelin pathway the go signal that also suppresses somatostatin, the off switch (Ipamorelin activates this) When you use both together, you are: Amplifying the GH signal (CJC-1295) Triggering GH pulses (Ipamorelin) Reducing the natural brake that limits GH release (Ipamorelin suppresses somatostatin) The result is a larger, more natural growth hormone pulse than either peptide produces alone

Nutrients 12(7):1987