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As with light sedation, benzodiazepines and opioids are most commonly used, but in higher amounts

Discussion This study on a cohort of 75 molecularly proven cEDS patients aimed to validate the revised diagnostic criteria and explore the multisystemic involvement of the disorder by comparing types and incidences of the numerous clinical manifestations at different ages and with those observed in other EDS subtypes, in order to delineate natural history and assist differential diagnosis

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The insular cortex lies deep in the brain and has widespread connections to surrounding regions