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As a mild stimulant, caffeine can cause various physiological effects common to stimulants such as increased alertness and attention, improved mood, increased heart rate, and reduced appetite

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Clinical research has shown that e-cigarettes can cause oxidative stress, mutations, dysfunction of heart cells, inflammation of the blood vessels, dysfunction of the endothelium (inner lining of the blood vessels), vasospasm (narrowing of the blood vessels), aggregation of platelets and increased risk of blood clots , hypertension (high blood pressure), tachycardia (increased heart rate), stiffening of the arteries, atherosclerosis (cholesterol deposition in the arteries), and increased risk of myocardial infarction ( heart attack )

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