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Risk increases more than 10-fold in smokers compared to non-smokers Smoking accounts for about 80% of cases, accelerates the decline in lung function Increases the risk of developing asthma and worsens symptoms Weakens immunity, increases susceptibility to infections Has a toxic effect on lung epithelium, causes oxidative stress and DNA damage Alters the composition of bacteria in the lungs, which may promote disease Increases the risk of asthma, infections, and reduced lung function in children and adults Cardiovascular system Smoking tobacco has a clearly negative impact on the cardiovascular system