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In the spirit of the-show-must-go-on, and with the help of a piano accompanist, Terry-Thomass character looks up at a notice that says DO NOT PANIC! and pretends nothing has happened by impersonating the vocalists on the broken records, however unlikely

Furthermore, a combinatorial approach targeting both NLRP3 activation and oxidative stress has been proposed as a promising therapeutic strategy, with the potential to restore small airway function, mitigate structural injury, and ultimately prevent disease progression ( Remodeling phase Proliferation of smooth muscle cellsFibrosisVascular Pruning Airway smooth muscle (ASM) in COPD small airway pathology commonly exhibits cellular hyperplasia and hypertrophy, leading to airway wall thickening, increased airway contractility, and directly contributing to small airway stenosis and airflow limitation (56, 57)

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By the 20th century, smoking was widespread worldwide, becoming a defining social habit before health concerns and regulatory efforts began to curb its prevalence