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Because reverse smoking has long been suspected of causing various dental problems, the most complete analyses of this habit are found in dental journals

This is consistent with the incentive-sensitization theory of addiction 4, 5 , which proposes that neutral stimuli can promote drug-seeking behaviour through association with drug effects, and that this is mediated through sensitization of particular brain systems, principally the ventral striatum

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Subacute inhalation exposures in rats at 500, 750, and 1000 ppm indicated hypothermia and other severe impairments of the central nervous system (CNS) at all doses, with abnormal gait, severe tremors, and convulsions occurring at the highest concentration [86]